Bio Monthly (November 2025): Micropayments for AI Scientists, Dog Longevity, Weights vs. Cardio
Highlights from the Biosphere 🌐 Bio's network of AI Agents for scientific research and health ("BioAgents") can now process instant USDC micropayments using @CoinbaseDev x402 + Embedded Wallets, laying the groundwork for an AI-driven coordination layer where human researchers, labs and AI Scientists can directly tr...
Bio's network of AI Agents for scientific research and health ("BioAgents") can now process instant USDC micropayments using @CoinbaseDev x402 + Embedded Wallets, laying the groundwork for an AI-driven coordination layer where human researchers, labs and AI Scientists can directly trade scientific knowledge and labor.
Upcoming Projects on the Bio Launchpad: DogYears (dog longevity therapeutic), Holi (Weights vs. Cardio fitness trial testing brain health markers), VitaSeno (CRISPR gene-editing to eliminate zombie cells).
Recently Launched Projects: Foxo3 (RNA therapeutic for degenerative disc disease), Neuron-Gale (targeting brain inflammation in Alzheimer’s) & Relieva (therapeutic cannabis for pain relief).
Scientific progress in the Bio ecosystem: Cerebrum DAO advances its brain health research to placebo-controlled human trials, VITARNA gene therapy successfully tested delivery vectors for human studies, and PsyDAO funded a research proposal for a new class of MDMA prodrugs.
Newsletter
Get the latest updates from the Bio ecosystem
New launches, research progress, and ways to get involved across the Biosphere.
Payment Rails for AI Scientists
Using Coinbase's x402 protocol, BioAgents can now issue and receive payments with third-parties: human-to-agent, agent-to-agent and agent-to-lab. The ability for BioAgents to pay for services and collect revenue on their own lays the groundwork for an onchain science economywhere AI Scientists can hire each other, access paywalled data, and reward contributions instantly.
Example use-cases:
Hypothesis & Knowledge Graph Refinement: Agents pay researchers who upload valuable new data, papers and findings to an agent's knowledge graph.
Pap-Per-Data Access: Agents host premium or proprietary datasets with fine-grained micro-billing per retrieval request.
Pay-Per-Analysis: Agents expose computational pipelines as on-demand services.
Agent-to-Agent Collaboration: Agents exchange computational insights with each other - e.g., Agent A (Genomics Specialist) sells preprocessed embeddings to Agent B (Drug Designer) which pays when retrieving cluster signatures.
BioAgents are agentic science machines designed to execute tasks and generate data in the R&D lifecycle. They continuously populate a knowledge graph, generate hypotheses, design experiments and help monetize discoveries. Earlier this month, the first BioAgent,@Aubrai_, a longevity AI scientist co-developed with the longevity researcherDr.@aubreydegrey and @vitadao, processed the first x402-enabled transaction, enabling Aubrai to issue and receive payments.
➤ Watch Coinbase GTM lead @The_Shark_7 demo the integration in this video
➤ Listen to last week's X Spaces featuring the founders of Foxo3 & DogYears DAO. Stay for interviews this week with the founders of Holi, VitaSeno & more.
Dive into upcoming launches on Bio 👇
Workshop: How to Fundraise with Bio
With the launch of Bio's new self-service researcher application and permissionless launches getting closer, we hosted a livestream exploring how to use Bio to fund and accelerate scientific research, featuring Bio's Chief Science Officer, @jamessinka, & Curetopia founder, @eperlste.
➤ Watch the workshop recording to learn more about the evolving DeSci Playbook & stay tuned for the next researcher workshop with biotech investors from Compound VC.
We announced Season 2 of Bio's staking program and loyalty layer - BioXP - which introduce new mechanics that re-engineer incentives on the network, drive additional rewards to BIO stakers (veBIO holders) and incentivize sustained support for newly launched tokens:
BIO Staking as the Foundation: Staking BIO (to generate veBIO) is now required in order to earn XP from ecosystem token staking.
Ecosystem Airdrops: veBIO holders passively earn automatic airdrops from new token launches.
Level Multiplier: Your veBIO balance unlocks boosted earning power up to 10X BioXP on ecosystem token staking.
New Token Multiplier: In the first 60 days after a new ecosystem token goes live, veBIO holders earn more XP for staking the ecosystem token.
Following the transition from Bio Season 1 to Season 2, BioXP 14-day expirationwas re-activated to reduce the total BioXP in circulation; meaning, each unit of BioXP will now generate a higher token allocation in upcoming sales.
We also haven't forgotten about yappers: We're gradually expanding the Bio Creator Program, inviting community voices to earn a slice of monthly XP. To qualify for an invite, keep pushing DeSci and share your posts in the "flex your post" topic of our Telegram/Discord.
Cerebrum DAO's Percepta project's clinical trial infrastructure is complete, with the first tokenized brain health supplement reaching double-blind placebo-controlled human trials soon. Their FissionBio project tested 90 compounds and identified 15 hits that block the DRP1-FIS1 interaction driving mitochondrial dysfunction, with plans to now scale to 600 compounds.Cerebrum's Transfidelity project is currently working on understanding the pathways their hit compounds need to modulate to optimize the compounds.
VitaDAO's $VITARNA project tested two clinically relevant delivery vectors for potential human studies. Both showed strong compatibility, giving the team a green light for scale-up and translational planning. Thelead researcher of VITARNA, @Mykalt45, won the Best New Drug Developer at this year's World ADC. VitaDAO's VitaSTEM project analyzed 850K+ hematopoietic stem cells from donors and identified 11 high-confidence rejuvenation targets with target prioritization powered by Scientific AI Agent @Aubrai_. VitaDAO announced Season 2 of VitaLabs, with special incentives for projects using Aubrai - apply here. Vita also hosted a community call covering VitaLabs outcomes, Aubrai IPT updates, portfolio company progress & more.
PsyDAO approved a $30,000 funding proposal to develop a new class of MDMA prodrugs to overcome the safety limitations and regulatory hurdles of MDMA-assisted therapy, such as cardiovascular risks, neurotoxicity, and abuse potential. The research focuses on developing a unique method to control the drug's release that could lead to a safer pharmacological profile with a more gradual onset and fewer side effects. Listen to PsyDAO's live session discussing the latest funding for MDMA prodrugs.
Pump Science-supported project, Blue Scorpion Venom, launched in partnership with Reputable Health, a human validation study with 35 participants using the world’s only Blue Scorpion venom–based homeopathic medicine. Theystarted the next worm experiments with DOCS becoming the new king of the pill, achieving a 80% lifespan extension. The first chemical reprogramming intervention was launched on Pump by the Reprogramming Lab & the Rapamycin Longevity Lab.
D1ckDAO partnered up with Welshare Health to match securely stored patient profiles, validate research hypotheses, and recruit participants for clinical trials in men's health in a privacy-preserving way. They also partnered with Episteme to launch their first prediction market, powered by a @D1ckGPT hypothesis, testing whether daily Panax Ginseng can improve erectile function on par with 5mg tadalafil (Cialis). The DAO is also hosting a meetup with Binance Thailand to activate the DeSci scene in Thailand & did a live demo of D1ckGPT at Thailand Blockchain Week.
Dog Years DAOregistered their first IP-NFT for their upcoming IPT on Bio developing Follistatin Gene Therapy for Canine Arthritis and Healthspan.
Bio is hosting DeSci Abu Dhabi in collaboration with @Molecule_sci on December 10 at the Cleveland Clinic featuring MIT neuroscience pioneer @eboyden3, Dr. Axel Bouchon from Matter Neuroscience, Pro Athlete James Magnusson & many more. RSVP or Apply to speak.
