Bio Monthly (April 2025): Scientific AI Agents, Virtual Cell Model, Patient #1 Study, Fungal Biotech

Highlights from the past month of bio acceleration:

• Bio released the first of its AI frameworks, the BioAgent elizaOS plugin, which converts scientific papers into structured knowledge that can be used by intelligent agents to generate biological hypotheses across scientific domains.

• Bio contributed to PrimeIntellect's decentralized training run, laying the groundwork for VitaDAO to partner with Harvard Medical School's AbuGoot Lab & PrimeIntellect to build a Virtual Cell Foundation Model for Longevity Research.

• Long COVID Labs launched its first case study using a combination therapy, with Patient #1 reporting early symptom relief.

• The Bio x AI Hackathon launched with 2 months of virtual hacking to create scientific AI agents, offering over $125K in prizes. The hackathon started with an in-person kick-off event in Berlin (all talks are live here). Join the Bio Discord #hackathon-chat to collaborate with fellow hackers or submit a solo project.

• MycoDAO was approved by Bio curation and launched their pre-sale fundraise, surpassing their minimum goal of 2.1K SOL within 48 hours. Sale closes May 12 or when the max cap is reached - Participate here.

• ‍SpineDAO was approved by Bio curation and launched their pre-sale fundraise to advance AI-driven spinal care innovations like surgical decision-mapping and IoT monitoring. Sale closes May 15 or when the max cap is reached - Participate here.

• Bio and VitaDAO hosted the DeSci Summit Dubai 2025 at the Museum of the Future during Token2049, featuring live talks from biotech and AI leaders from Roivant Sciences, Apeiron Investment Group, Insilico Medicine & more - watch the full day of talks on our Youtube.

🌐 Enter the Biosphere 🌐

💻 Dev Updates

• Vending Machine proposed a new long-term staking model for $BIO and value accrual for the Bio treasury, enabling users to earn BioDAO tokens and IP-Tokens through staking - See the proposed design.

• Another discussion explores integrating Molecule's IP-Tokens into the protocol, allowing scientists to raise direct funding for individual research projects via Bio, and the Bio protocol treasury to accrue tokenized biotech assets in its treasury - Check out the post.

• The newly introduced BioAgent elizaOS plugin is an open-source plugin allowing researchers to transform papers into decentralized knowledge graphs, empowering AI agents to generate and evaluate biological hypotheses. Watch it process a VitaDAO repo for the Longevity Atlas challenge in the Bio x AI Hackathon.

• Bio contributed 8 H100 GPUs to INTELLECT-2, the first decentralized 32B-parameter Reinforcement Learning training run from Prime Intellect.

💡New BioDAOs

• Long COVID Labslaunched their case studies for Pemgarda and Paxlovid to target viral persistence and patient #1 already documented early symptom relief. Long Covid Labs will monitor viral persistence biomarkers across multiple measurement tools and assays, and plans to collect decentralized data from their community to fuel their rapid trial engine and deploy personalized therapies targeted to an individual's biomarker profile.

• MycoDAO passed Bio Curation and started its pre-sale fundraise which reached its minimum goal of 2.1K SOL in just 48 hours. The pre-sale fundraise is live until May 12, after which $MYCO will go live for trading. The DAO also introduced a new device that integrates with their MycoWallet app, rewarding users who contribute real-world mushroom data that can be leveraged by Myco's Multi-Agent System (MAS) to generate new therapeutics, materials and climate solutions.

• SpineDAO launched their token auction & have raised over $200K so far (closing May 15) - Contribute here. As part of the Bio x AI Hackathon, Spine discussed the "Chronos" project aimed at building a knowledge graph that links historical spine texts with modern surgical methods. The DAO also partnered with Spinal Alignment Solutions (SAS), the first spine surgery industry leader to invest in $SPINE, enabling SAS to leverage SpineDAO's AI and data infrastructure to accelerate spine R&D.

• Curetopia are growing ARS yeast avatars in the lab. Expect initial results soon, along with their plans to scale the research to 30 ARS gene-related rare diseases. They also announced their Q2 budget & 16–20-week timeline, targeting results by July 4 & introduced the Curetopia core team. The DAO also spoke at DeSci Summit Dubai & Vitalist Bay & launched a 12-part series on rare disease parents & patients, with 3 parts already released.

• Quantum Biology DAO and Portland State University found that killifish embryos show altered growth in a hypomagnetic chamber& will study across species to explore life's reliance on Earth's magnetic.

🌐 Network Updates

• VitaDAO presented their vision to create a decentralized knowledge network mapping the hallmarks of aging and an AI-driven hypothesis generation engine. This comes on the heels of Vita's plans to develop a multimodal Virtual Cell foundation model with Prime Intellect and the AbuGoot Lab at Harvard Medical School, accelerating longevity research & AI-driven drug discovery.

• HairDAO analyzed 25 RNA samples that are over 90% high quality, with only one slightly below ideal. The DAO is also offering 0.5 $HAIR for completing a survey about their telehealth platform, which has just released their most potent hair regrowth product to date. The DAO is giving early access to their latest findings on T3 & T4 thyroid hormones and their impact on hair growth - Sign up here.

• ValleyDAO's Cocoa Zero yeast strain produced fats 90% identical to organic cocoa butter - learn more. Their Q1 update highlighted Hempy’s eco-friendly hemp textiles and their Cocoa Zero project. They also released new Proof of DeSci episodes with Episode 2 exploring quantum biology & BioAgents, Episode 3 discussing MIT's How to Grow Almost Anything program, and Episode 4 focusing on their Cocoa Zero project.

• Cerebrum DAOreleased their Q1 report, showcasing their token launch on Base, key partnerships, funding for projects like FissionBio, Artic Therapeutics & more. The DAO also showcased their new brain health app at DeSci London, and co-hosted a virtual event with Molecule and the scientists behind the Transfidelity project.

• PsyDAO's DMXE projects' lab protocols and study were submitted for ethics review to complete data collection for milestone 1. They also hosted the AI x Science Hackathon with Google for Education, focused on advancing scientific discovery using AI tools.

• AthenaDAO hosted the Fertility Acceleration track at Vitalist Bay with talks on reproductive longevity & participated in a panel at the Harvard Blockchain Conference.

• Pump Science were highlighted together with VitaDAO by Cointelegraph for leveraging crypto to fund longevity research. They also shared a progress update, including a collaboration with Meteora on fairer token launches, fly racing with leverage trading & more. Pump Science also outlined their research protocol for conducting autonomous science at DeSci Dubai& participated in the Harvard Blockchain Conference.

• Molecule revamped their website, turning it into a DeSci discovery engine for exploring, tracking, and trading tokenized scientific IP. They also shared a new article highlighting NIH's funding cuts, with DeSci offering a promising alternative for researchers.

• CryoDAO are launching the American Biostasis Foundation to build the leading cryopreservation facility for humans and pets. They outlined their plans for the cryopreservation facility and why cryo matters at Vitalist Bay.

🧬 Bio Community Updates

• We launched the Bio Ecosystem account to provide real-time updates on the ecosystem, including founder progress, funding rounds, and Bio x AI developments, while keeping the main account focused on the core protocol and tech - Follow our Bio Ecosystem account

• ‍Watch all the DeSci Dubai talks, including talks by YZi Labs, Roivant Sciences, InSilico Medicine, Apeiron Investment Group and more.

• Olas highlighted Sean Brennan's talk on BioAgents on the Agents Unleashed podcast. In May, Sean will present how decentralized knowledge graphs co-owned by BioDAOs are advancing agentic science at the OriginTrail Decentralized Knowledge Graph Conference.

• Messari Research highlighted how decentralized patient data can reinvent the scientific value chain, noting that "various BioDAOs coming out of Bio are working toward sourcing data for AI development within their specific field, tackling challenges that would be difficult to solve with publicly available data."

• Bio's new podcast "DeSci Pilled" released three new episodes, including episodes with HairDAO, MycDAO and the latest episode with BoostVC founder Adam Draper on science thriving beyond academia through virtual labs and creator economies.

• Bio co-founder, Paul Kohlhaas, outlined $BIO as a bet on DeSci's growth, aiming for 5-10 DAOs and 20-30 IPTs quarterly, using AI agents to accelerate science and funding.

• Bio's Science Lead James Sinka appeared on Adam Draper's podcast to explore DeSci, how researchers can earn financial rewards and recognition, and more.

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