Bio Monthly: Bio Season 2, x402 Payments x DeSci Agents, eDMT on Rogan, HSC Aging, Stack Analysis

Highlights from the last month in the Biosphere 🌐

• Bio Launchpad Season 2 Preview: Permissionless Pools, Ecosystem Airdrops, Limit-Sell Fundraising, BIO Staking upgrades.
• x402 Payments x BioAgents: Integration of x402 into Bio's Scientific AI Agents to open up new forms of autonomous scientific discovery and commerce.
• Ignition Sales: $VITASTEM targeting rejuvenation of blood-forming stem cells, and @D1ckGPT, BioAgent providing personalized Men's Health advice and trained on live studies.

• Research applications are now open to scientific researchers seeking $50,000-$250,000 in funding and incubation in the Bio Network.

• + more!

Bio Launchpad Season 2 Coming

Season 1 of the Bio Launchpad generated a wealth of data and learnings across our first 5 BioAgent and IP Token launches, with 8k+ participants funding innovations in stem cell research, men’s health, psychedelic science & more.

We announced Bio Season 2, including key upgrades to BioXP, Ignition Sale and staking mechanics, as well as integrations with @Coinbase x402 to power scientific AI agent commerce, ecosystem airdrops, @aerodrome pool launcher & @BNBCHAIN.

With S2, Bio is evolving from a high-touch launchpad into a permissionless factory for decentralized biotech.

Dive into the article below for more details on Season 2 ↓

x402: Payment Rails for Agentic Science

BioAgents are “agentic science machines” - continuous AI-driven workers designed to execute tasks in the R&D lifecycle, such as reading literature, hypothesis generation, and designing experiments. They are trained on custom datasets uploaded to knowledge graphs and curated by researchers and distributed research communities.

The first BioAgent, @Aubrai_, a longevity AI co-scientist co-developed in partnership with @vitadao and the renowned longevity researcher Dr. @aubreydegrey, is conducting API dev testing that will enable Aubrai to receive and issue payments via x402. The functionality will be extended to the open-source BioAgent framework, allowing Bio's network of BioAgents to coordinate across different research domains and offer services to third-parties: human-to-agent, agent-to-agent and agent-to-lab.

The x402 payment protocol by Coinbase will be used to issue and receive payments across this emerging economy of DeSci agents, unlocking a number of potential use-cases, such as:

• Hypothesis & Knowledge Graph Refinement: Agents compensate researchers who provide hypothesis feedback or improve agent intelligence by uploading new data, papers and findings to an agent's knowledge graph.
• Agent-to-Agent Collaboration: Agents exchange computational insights - eg., Agent A (Genomics Specialist) sells preprocessed embeddings, Agent B (Drug Designer) pays via x402 when retrieving cluster signatures.
• Pay-Per-Analysis: Agents expose computational pipelines as on-demand services.
• Pap-Per-Data Access: Agents host premium or proprietary datasets with fine-grained micro-billing per retrieval request.

Stay tuned for upcoming x402 releases as part of the upgraded open-source BioAgent framework launching in Bio Season 2.

Ignition Sale Launches: VitaSTEM & D1ckGPT

Two exciting new projects went live on Bio:

1. VitaSTEM aims to reverse aging through rejuvenation of your body's blood-forming stem cells. It is the first IP Token generated by the scientific AI agent @Aubrai_. The Aubrai agent was used by VitaLabs contributor Dr. @AshishMedbt to rapidly pinpoint molecular targets in his research, saving 100s of hours of human work and demonstrating the potential of human researchers and AI Agents to collaborate on pioneering research. VitaSTEM's team analyzed 850K single-cell transcriptomes of hematopoietic stem cells (HSCs) across ages and identified lead target genes for rejuvenation. The VitaSTEM project will now validate these targets in vitro using RNA-based interventions and small molecules. Validated interventions could reverse HSC aging, opening a new path in regenerative medicine, and enabling multi-modal strategies to improve healthspan and combat age-related decline.

➤ See the VitaSTEM roadmap, or learn more about the project in the Bio App.

2. D1ckGPT: The first Men's Health BioAgent,@D1ckGPT gives recommendations for men's health optimization while collecting verifiable data to fuel research breakthroughs. Trained on 600+ clinician-curated studies and based on its own ever-evolving Knowledge Graph, D1ckGPT provides personalized stack suggestions (supplements, sleep, diet) and calculates a proprietary D-Age to help men track and reverse biological decline. Connected to live men's health clinical studies conducted by a collective of Thailand-based doctors specializing in male sexual health, as well as, every interaction enhancing the agent's intelligence, creating a flywheel that funds new research and products, and democratizes discovery in men's health. The agent is accessible via X by tagging @D1ckGPT, Discord, and the upcoming privacy-focused D1ck Terminal. ➤ Sign up for the D1ck Terminal waitlist.

➤ See the D1ckGPT roadmap, tag @D1ckGPT on X to get science-backed men's health advice, learn more about D1ckGPT in the Bio App.

Bio Listed on UpBit

Bio's month-long Asian tour this past month was capped off by the $BIO token being listed today on leading South Korean exchange Upbit (@Official_Upbit).

The listing helps lay the groundwork for wider adoption of Bio and DeSci, uniting two unstoppable forces: onchain finance and Asia’s rapidly compounding biotech renaissance.

Apply to Launch with Bio

With the upcoming launch of Season 2, Bio is opening its doors to more researchers to launch on Bio. We are hosting a livestream on Nov 6 exploring how to use Bio to fund and accelerate scientific research featuring Bio science lead, @jamessinka, & Curetopia founder, @eperlste.

➤ Apply to attend the livestream on Nov 6 at 1pm EST.

Bio helps researchers with:

• User-friendly tools to fund, coordinate & commercialize your research
• End-to-end blockchain logistics, so you can focus on science
• Access to a global network of investors & early adopters
• Branding and design support to make your work market-ready
• Legal setup for compliant token launches

➤ Apply to launch with Bio

➤ Refer a researcher who launches with Bio and earn 20K $BIO

➤ Learn more about launching with Bio

Ecosystem Updates

• PsyDAO's lead researcher of their eDMT project went on the The Joe Rogan podcast discussing the chemical process they are studying to understand how to regulate DMT production in the brain. PsyDAO is also running the first systematic study on microbiome & psychedelic interaction in Patagonia in partnership with @microbiomedao as part of their psychedelics week at Edge City.
• VitaDAO are testing whether AI can design better longevity drug combinations than humans using the Aubrai agent & other AI models, with upcoming IP Token launches based on top-performing combinations. They also presented at the Nordic Aging Conference, highlighting @Aubrai_ & a VitaDAO-supported project received an award for research on small molecules to slow dementia. They are also hosting a community call on Nov 7, sharing a VitaLabs Season 1 & Season 2 report, Aubrai IPT launches & data mining for RMR2, a VitaDAO PortCos update, the next IPT launch & more. RSVP.
• Curetopia analyzed their 10 ARS drug screens, doing high-throughput screen of 8,400 compounds, revealing that mitochondrial ARS2 variants respond better to rescuer compounds with fewer sensitizers compared to cytoplasmic ARS1 variants across five amino acids. These efforts could expose vulnerabilities that can accelerate therapies for ARS disorders. Curetopia also discussed autophagy, their RAPTOR project, and morewith renowned neuroscientist David Rubinsztein & Pump Science.
• Cerebrum DAO outlined the upcoming Neuron Gale IPT launch on Bio in a broadcast with the scientists behind the project, including testing a small molecule, previously used in peripheral indications, for treating neuroinflammation in an Alzheimer’s mouse model. They also hosted their Quarterly AMA Townhall discussing progress across their portfolio of IP assets & research projects & attended the Bio Camp by Boost VC. Cerebrum are also about to enter the beta testing phase for their Cerebrum Cortex app. Apply to get early access.
• ValleyDAO presented their upcoming Tattva IPT, funding carbon-negative biomaterials that grows in just seven days, locking in ~1 tonne of CO₂ for every 4m³ produced. Their HEMPY project's lead scientist also presented their hemp breakthroughs and their upcoming limited-edition apparel line is looking for an entrepreneur in residence for the project. Apply here. They also spoke at Grand Jamboree in Paris discussing how they are advancing the future of climate biotech.
• Quantum Biology DAO is hosting the first ever Quantum Biology Hackathon, inviting interdisciplinary teams to explore quantum phenomena in biological processes. They are also doing experiments to detect fluorescence changes in bacteria with a magnetically responsive protein under pulsed magnetic fields to test whether quantum mechanisms are at play. The team built a new AI-driven graphical user interface (GUI) to streamline operations & coordinate experiments for their platform screening magnetosensitivity in bacterial plates.
• AthenaDAO's OVARIA project is developing a Menopause Risk Model using ML to correct biases in self-reported data, identifying biological targets between earlier menopause and diseases like osteoporosis and endometriosis and are moving into drug discovery and development.
• HairDAO has now produced over 5TB of research data and are releasing their precision dutasteride formulation on Nov 11. They also installed a coverslip automater to enhance analysis efficiency & enable the lowest cost per study in the US for hair loss research including their first 100% in-house paper with exclusive access to HAIR and LAB holders. Soon their open-source staking protocol will go live for their HAIR token.
• Pump Science's Season 2 of the F1y Grand Prix went live focused on real fly races on tokenized performance enhancing compounds, with Rapamycin winning the first race. They have now funded 125 longevity experiments & are launching new worm experiments soon.
• Biome's BioAgent, @BiomeAI, offering personalized microbiome health advice & research, shared a demo of the BioAgent in a showcase with the elizaOS community.
• SpineDAO's co-founder Bassel Diebo won "The Oscars of Spine" for his contributions to spine care. The team is advancing their decentralized Spine AI Suite with contributions verified through Soulbound Tokens.
• DermaDAO's new line of skincare products is coming.
• Molecule are hosting a DeSci talk & workshop at Berlin Science Week & shared their monthly recap of the latest developments across Molecule & the broader DeSci ecosystem throughout September.
• Dog Years DAO's website went live & they launched a prediction market with Episteme, for their first clinical study, testing whether follistatin gene therapy can restore vitality in aging dogs.
• FatDAO are advancing new products designed to target metabolic health.
• Spectruth DAO hosted an AMA diving into the latest updates on their PTSD clinic.

Community Updates

• All talks from this year's DeSci Singapore were published on Bio's Youtube channel & key takeaways on X. Talks include a fireside chat with @CryptoHayes & Bio founder
• @paulkhls, a talk by D1ckDAO on their new D1ckGPT agent, Dr. Aubrey de Grey & VitaDAO presenting the Aubrai agent live on stage, and Molecule CBO Aaron Weaver leading a panel with top biotech operators & investors on the Golden Age of Biotech: What is Hype & Bluster?
• @shelbynewsad of Compound VC published an article exploring the DeSci Playbook, naming Bio's launchpad as a key tool for funding and coordinating decentralized science.
• @juniper_vc, the Bioindustrial venture capital fund, featured Molecule, VitaDAO and ValleyDAO  in their article on "Alternative Funding Tools & Models for Science".
• The Agentic AI Against Aging Hackathon concluded after weeks of building agentic AI systems to fight aging, with winners announced soon.
• Bio Protocol-owned assets were migrated to Aerodrome & staked to earn emissions.
• BIO went live on DefiLlama, enhancing DeFi analytics.
• The Presto Research Podcast featured Bio founder Paul Kohlhaas, diving into his journey from biohacking to founding Bio, DeSci's solutions to science funding inefficiencies, IP ownership, direct-to-consumer channels & more.
• Bio, AthenaDAO, & Spectruth DAO joined The Aggregated ep. 133 X Spaces with QuickSwap to discuss the latest DeSci developments.
• Bio CEO, Paul Kohlhaas, was interviewed by Eva from AuraSci, diving into the latest DeSci developments and how the ecosystem is scaling faster than ever.
• Bio was featured by BSCN covering our latest ecosystem developments and Upbit listing.
• DeSci Türkiye & Bioexpo Instanbul hosted an event focused on next-gen science, sponsored by Bio, Trio Blockchain Labs, Scirise, & more.
• The DeSci Unites event will take place on November 10 to uncover how DeSci can accelerate longevity research featuring Molecule, Bio, Longevity Biotech Fellowship, Pump Science, & more.
• Bio's podcast, DeSci Pilled, released a new episode with Eleanor Davies from Sei Foundation, discussing onchain health data and the future of self-sovereign science & a new episode with D1ckDAO.
• We published a short video explainer of how Bio works in a nutshell.

Explore New DeSci projects on the Bio App

Stay updated via our Telegram, Discord,Governance forum. Follow @BioProtocolEco on X for real-time ecosystem updates.

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