Highlights from the Biosphere 🌐
Payment Rails for AI Scientists
BioAgents can now pay for data and services on their own by using @CoinbaseDev's x402 + Embedded Wallets for instant USDC micropayments on @base. This allows Bio's network of Scientific AI Agents to coordinate across different research domains and offer services to third-parties: human-to-agent, agent-to-agent and agent-to-lab.
BioAgents are “agentic science machines” - continuous AI-driven workers designed to execute tasks in the R&D lifecycle, such as reading literature, hypothesis generation, and designing experiments. They are trained on custom datasets curated by researchers and distributed research communities.
The first BioAgent, @Aubrai_, a longevity AI scientist co-developed in partnership with @vitadao and the renowned longevity researcher Dr. @aubreydegrey, became the first x402-powered BioAgent, enabling Aubrai to receive and issue payments.
The integration unlocks a number of potential use-cases, such as:
- Hypothesis & Knowledge Graph Refinement: Agents compensate researchers who provide hypothesis feedback or improve agent intelligence by uploading new data, papers and findings to an agent's knowledge graph.
- Agent-to-Agent Collaboration: Agents exchange computational insights - eg., Agent A (Genomics Specialist) sells preprocessed embeddings, Agent B (Drug Designer) pays via x402 when retrieving cluster signatures.
- Pay-Per-Analysis: Agents expose computational pipelines as on-demand services.
- Pap-Per-Data Access: Agents host premium or proprietary datasets with fine-grained micro-billing per retrieval request.
➤ Watch Coinbase GTM lead @The_Shark_7 demo the integration in this video.
➤ Build on the new x402-compatible BioAgent framework or test Aubrai payments on x402scan.
➤ Learn more about x402 & BioAgents ↓
Bio S2 Launch Mechanics & Upcoming Launches
We hosted a Bio Open Lab Spaces diving into the recently announced details on Bio Launchpad Season 2 and the next projects to launch.
Highlights ↓
➤ First S2 Ignition Sales
- $DROPS - Skin Longevity Serum supported by @dermadao
- $GALE - Brain Inflammation Shield supported by @Cerebrum_DAO
- More IP Tokens & BioAgents across synbio, longevity & neuroscience coming
➤ S2 Launch Mechanics
- Sales switch to USDC for cleaner routing, permissionless launches & less risk to BIO holders
- As project FDV clears tiers and holds ≈2 weeks, USDC is unlocked for research funding
- Winners later get a BIO pair; weaker experiments don’t drag BIO price
➤ Staking, XP & Airdrops
- Stake BIO → earn BioXP → use BioXP + USDC to access sales
- Ecosystem airdrops to BIO stakers
- BIO stakers earn Multipliers that boost BioXP rewards for staking new ecosystem tokens in their first 60 days.
➤ Launchpad & Liquidity
- Integration with @AerodromeFi on Base; pool launcher used from day one
- Eligible tokens get Coinbase DEX Trading visibility at launch
- BNB bridge for BIO approved by governance & launchpad coming to BNB
➤ Listen to the Bio Open Lab covering S2 Mechanics, as well as live interviews with the founders of DROPS & GALE, launching soon on Bio.
Workshop: How to Fundraise with Bio
With the upcoming launch of Season 2, we hosted a livestream exploring how to use Bio to fund and accelerate scientific research, featuring Bio's Chief Science Officer,
@jamessinka, & Curetopia founder, @eperlste.
➤ Apply now to fund your research on Bio
➤ Watch the workshop recording to learn more about the evolving DeSci Playbook ↓
Ecosystem Updates
- Cerebrum DAO's Percepta project's clinical trial infrastructure is complete, with the first tokenized brain health supplement reaching double-blind placebo-controlled human trials soon. They also shared more about the research behind their upcoming IPT, NEURON-GALE, launching on Bio soon.
- VitaDAO announced S2 of VitaLabs, prioritizing projects using @aubrai_ for hypothesis generation, experiment design, and science development - apply here. The lead researcher of VITARNA won the Best New Drug Developer at this year's World ADC & they hosted a community call covering VitaLabs S1 outcomes, @Aubrai_ IPT updates, PortCos progress & more. Vita also opened up 3 job openings across AI Engineering, Growth & Operations.
- HairDAO have spent $260K testing 60+ dutasteride delivery vehicles & released their precision dutasteride, based on their lessons. Learn more about their formulation & order here.
- Curetopia shared the initial mouse study results on their $RAPTOR intervention within less than 3 months since token launch. The results showed that a low-dose enhanced grip strength and endurance via balanced autophagy modulation, while a higher dose triggered hypothermia and immune stress.
- Quantum Biology DAO hosted the first ever quantum biology hackathon, with 29 contributors coming together to develop 6 different projects exploring how quantum effects might influence living systems.
- Pump Science started the next worm experiments with DOCS becoming the new king of the pill, achieving a 80% lifespan extension. The first chemical reprogramming intervention was also launched on Pump Science by the Reprogramming Lab & the Rapamycin Longevity Lab.
- D1ckDAO partnered with Episteme to launch their first prediction market, powered by a @D1ckGPT hypothesis, testing whether daily Panax Ginseng can improve erectile function on par with 5mg tadalafil (Cialis) & did a live demo of D1ckGPT at Thailand Blockchain Week.
- MicroDAO shared their Q3 update, highlighting their Pathogen Catalogue, delivering key pathogen metrics and data, launching by year-end, their Collective Research Platform, guiding researchers end-to-end, entering closed alpha in early 2026, and their Economic Impact Calculator, modeling fiscal effects of pathogen interventions, reaching alpha testing in early 2026.
- SpineDAO presented their AI suite at the SOFCOT CAOS event in Paris.
Community Updates
- @CryptoHayes discussed his long-term outlook on BIO and DeSci live on stream (at 26:00)
- BSCN published an article on BioAgents and x402 driving autonomous science.
- The Agentic AI Against Aging Hackathon sponsored by Bio was featured in Longevity Technology.
- Bio sponsored a 25,000 $BIO prize for the Longevity Agents × Berlin Hackathon where Bio's Head of AI @AakaashMeduri hosted a workshop on how to use the open-source BioAgents framework.
- @DeSciNews hosted the Bio Ecosystem Mega Space featuring Bio, Curetopia, ValleyDAO, Cerebrum DAO, SpineDAO, & Long COVID Labs.
- DeSci Pilled, Bio's podcast, released a new episode with Biome.
Explore New DeSci projects on the Bio App.
Stay updated via our Telegram, Discord, Governance forum. Follow @BioProtocolEco on X for real-time ecosystem updates.
